6- (Dimethylamino) purine

6- (Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6- (Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6- (Dimethylamino) purine can affect the maturation of mammalian oocytes. 6- (Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis) [1][3][5].

Product Specifications

CAS Number

[938-55-6]

Product Name Alternative

6-Dimethylaminopurine; 6-DMAP

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; CDK; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-dimethylamino-purine.html

Purity

99.90

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(C)C1=C2NC=NC2=NC=N1

Molecular Formula

C7H9N5

Molecular Weight

163.18

Precautions

H315, H319

References & Citations

[1]Szöllösi MS, et al. Inhibition of protein kinases by 6-dimethylaminopurine accelerates the transition to interphase in activated mouse oocytes. J Cell Sci. 1993 Mar;104 (Pt 3) :861-72. |[2]Ledda S, et al. The effect of 6-dimethylaminopurine (6-DMAP) on DNA synthesis in activated mammalian oocytes. Zygote. 1996 Feb;4 (1) :7-9. |[3]Bayat-Sarmadi M, et al. 6-Dimethyl amino purine and 2-amino purine inhibit the induction of expression of milk protein genes by prolactin. Biosci Rep. 1992 Jun;12 (3) :189-97. |[4]Ogneva IV. Mouse and Fly Sperm Motility Changes Differently under Modelling Microgravity. Curr Issues Mol Biol. 2021 Jul 5;43 (2) :590-604. |[5]Nakashima M, et al. Apoptosis induced by an alkylated purine, 6-dimethylaminopurine, and changes in gene expression in human lymphoma U937 cells. Anticancer Res. 2008 Mar-Apr;28 (2A) :609-20.