FAZ-3780
FAZ-3780 (compound G3Ib) is an inhibitor of binding to the NTF2L domain of G3BP1/2 that binds to G3BP1 with a Kd of 0.15 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2 and specifically inhibits co-condensation of G3BP1, caprin 1, and RNA in vitro[1].
Product Specifications
CAS Number
3036029-78-1
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/faz-3780.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C)C(N1CCC[C@@H]1C2=CC=CC=C2)=O)[C@@H](NC([C@H](C(C)(C)O)NC(CCC(C)(C)C)=O)=O)[C@@H](C)C3=CC=CC=C3
Molecular Formula
C35H50N4O5
Molecular Weight
606.80
References & Citations
[1]Brian D Freibaum, et al. Identification of small molecule inhibitors of G3BP-driven stress granule formation. J Cell Biol. 2024 Mar 4;223 (3) :e202308083.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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