Biotinylated Human C1q R1 / CD93 Protein, His, Avitag™

CD antigen CD93 is also known as Complement component C1q receptor (C1QR1) . which belongs to the Group XIV C-Type lectin family, a group containing two other members, endosialin (CD248) and thrombomodulin. CD93 contains one C-type lectin domain and five EGF-like domains. CD93 is highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA) . CD93 may mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and may play a role in intercellular adhesion.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 62.0 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q9NPY3-1

Expression Region

Thr 22 - Lys 580

Host

HEK293

Target

C1q R1

Conjugation

Biotin-labeled

Tag

C-10xHis & C-Avi

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Bioactivity

Immobilized Human IGFBP-7, Fc Tag (Cat. No. IG7-H5259) at 5 μg/mL (100 μL/well) can bind Biotinylated Human C1q R1, His,Avitag (Cat. No. C11-H82E9) with a linear range of 1-31 ng/mL (QC tested).