Fexofenadine (hydrochloride)

Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].

Product Specifications

CAS Number

[153439-40-8]

Product Name Alternative

MDL-16455 (hydrochloride) ; Terfenadine carboxylate (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Fexofenadine-hydrochloride.html

Purity

99.94

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C(C)(C)C1=CC=C(C(O)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2)C=C1.[H]Cl

Molecular Formula

C32H40ClNO4

Molecular Weight

538.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4 (3) :367-75.|[2]Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts. Allergy Asthma Immunol Res. 2014 Nov;6 (6) :567-72.|[3]Ming X, et al. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Mol Pharm. 2011 Oct 3;8 (5) :1677-86.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

H1 Receptor

Citation 01

Drug Metab Dispos. 2025 Mar;53 (3) :100046.|Int Immunopharmacol. 2023 Mar:116:109637.|Adv Mater Technol. 2023 Jan 29.|Biomed Pharmacother. 2024 Jun:175:116644.|Pharmacol Res. 2023 Apr:190:106724.