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P2Y6R antagonist 1

P2Y6R antagonist 1 (compound 5ab) is a selective, orally active P2Y6R antagonist with an IC50 value of 19.6 nM. P2Y6R antagonist 1 has anti-inflammatory activity[1].

Product Specifications

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/p2y6r-antagonist-1.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CCC(N1N=C(C2=CC=CN2)CC1C3=CC4=CC=CC=C4N=C3)=O

Molecular Formula

C20H18N4O3

Molecular Weight

362.38

References & Citations

[1]Zhao Y, et al. Discovery of a potent, Highly selective, and In vivo anti-inflammatory Efficacious, P2Y6R antagonist with a novel quinoline-pyrazole scaffold. Eur J Med Chem. 2024 Sep 23;279:116890.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2Y6 Receptor

Available Sizes

Frequently Asked Questions

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