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PDE1-IN-9

PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS) . PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes[1].

Product Specifications

CAS Number

2982945-41-3

UNSPSC

12352203

Target

Interleukin Related; NO Synthase; Phosphodiesterase (PDE) ; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pde1-in-9.html

Smiles

N#CC1=C(C2CCCC2)C3=C(C=C(NCC4CCOCC4)C=C3)N(CC5=CC=CC=C5)C1=O

Molecular Formula

C28H31N3O2

Molecular Weight

441.56

References & Citations

[1]Zhou Q, et al., Design, synthesis, and evaluation of quinolin-2 (1H) -ones as PDE1 inhibitors for the treatment of inflammatory bowel disease. Bioorg Chem. 2024 Nov 19;154:107979.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

IL-1; IL-6; PDE1

Available Sizes

Frequently Asked Questions

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