TRPV1 antagonist 9
TRPV1 antagonist 9 (compound 13c) is an orally active transient receptor potential vanilloid 1 (TRPV1) channel antagonist. TRPV1 antagonist 9 blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 values are 0.6 and 0.8 nM for Capsaicin (HY-10448) and acid-induced Ca2+ uptake, respectively. TRPV1 antagonist 9 blocks Capsaicin (HY-10448) -induced flinch response and causes hyperthermia in rats[1].
Product Specifications
CAS Number
[939040-79-6]
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trpv1-antagonist-9.html
Smiles
NC1=NC(C(NC1=O)=CC=C2)=C2OC3=NC(NCCOC)=NC(C4=CC=C(C(F)(F)F)C=C4)=C3
Molecular Formula
C22H19F3N6O3
Molecular Weight
472.42
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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