PKCTheta-IN-2
PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC50 of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases) . PKCTheta-IN-2 inhibits the IL-2 production in a mouse (IC50 of 682 nM) [1].
Product Specifications
CAS Number
1810742-60-9
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pkctheta-in-2.html
Purity
99.49
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C[C@H](C1=CC=CC=C1)N2C3=CC(N4C5=CC=CN=C5NC4=O)=CC=C3C(NC2(C)C)=O
Molecular Formula
C24H23N5O2
Molecular Weight
413.47
References & Citations
[1]Taisuke Katoh, et al. Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4 (1H) -ones as potent and selective PKCθ inhibitors. Bioorg Med Chem. 2016 Jun 1;24 (11) :2466-2475.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCθ
Available Sizes
Frequently Asked Questions
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