PKCTheta-IN-2

PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC50 of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases) . PKCTheta-IN-2 inhibits the IL-2 production in a mouse (IC50 of 682 nM) [1].

Product Specifications

CAS Number

[1810742-60-9]

UNSPSC

12352005

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pkctheta-in-2.html

Purity

99.49

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@H](C1=CC=CC=C1)N2C3=CC(N4C5=CC=CN=C5NC4=O)=CC=C3C(NC2(C)C)=O

Molecular Formula

C24H23N5O2

Molecular Weight

413.47

References & Citations

[1]Taisuke Katoh, et al. Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4 (1H) -ones as potent and selective PKCθ inhibitors. Bioorg Med Chem. 2016 Jun 1;24 (11) :2466-2475.