Azido-PEG6-NHS ester
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
2055014-64-5
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg6-nhs-ester.html
Purity
98.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C19H32N4O10
Molecular Weight
476.48
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers
Available Sizes
Frequently Asked Questions
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