Bragsin1
Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].
Product Specifications
CAS Number
369631-68-5
UNSPSC
12352005
Target
Arf Family GTPase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Bragsin1.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1C=C(C(F)(F)F)OC2=CC=C(C)C([N+]([O-])=O)=C21
Molecular Formula
C11H6F3NO4
Molecular Weight
273.16
References & Citations
[1]Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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