Cyclopiazonic acid

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B[1][4][5].

Product Specifications

CAS Number

[18172-33-3]

UNSPSC

12352005

Hazard Statement

H300

Target

5-HT Receptor; Apoptosis; Calcium Channel; MDM-2/p53; RSV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cyclopiazonic-acid.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C(C)=O)=C(O)[C@@]([C@]23[H])([H])N1C(C)(C)[C@]2([H])CC4=CC=CC5=C4C3=CN5

Molecular Formula

C20H20N2O3

Molecular Weight

336.38

Precautions

H300

References & Citations

[1]Bonyadi F, et al. Cyclopiazonic acid induced p53-dependent apoptosis in the testis of mice: Another male related risk factor of infertility. Environ Toxicol. 2021 May;36 (5) :903-913. |[2]Selli C, et al. Cyclopiazonic acid alters serotonin-induced responses in rat thoracic aorta. Vascul Pharmacol. 2014 May-Jun;61 (2-3) :43-8. |[3]Chen Q, et al. Inhibitory Effects of Cyclopiazonic Acid on the Pacemaker Current in Sinoatrial Nodal Cells. Neuroscience. 2020 May 1;433:230-240. |[4]Cui R, et al. Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus. Antiviral Res. 2016 Aug;132:38-45. |[5] Kuilman-Wahls ME, et al. Cyclopiazonic acid inhibits mutagenic action of aflatoxin B (1) . Environ Toxicol Pharmacol. 2002 Jul;11 (3-4) :207-12.