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PCSK9-IN-9

PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM[1].

Product Specifications

UNSPSC

12352005

Target

PCSK9

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pcsk9-in-9.html

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C/C=C\CCCCCCCC1=CC2=C(C(O)=CC(O)=C2)C(O1)=O

Molecular Formula

C26H36O4

Molecular Weight

412.56

References & Citations

[1]Pel P, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega, 2022.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Frequently Asked Questions

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