Eplerenone

Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB) . Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) [1][2].

Product Specifications

CAS Number

[107724-20-9]

Product Name Alternative

Epoxymexrenone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Mineralocorticoid Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/eplerenone.html

Purity

99.81

Solubility

DMSO : 23.33 mg/mL (ultrasonic)

Smiles

O=C(CC1)O[C@@]21CC[C@@]3([H])[C@]4([H])[C@H](C(OC)=O)CC5=CC(CC[C@]5(C)[C@@]46[C@H](O6)C[C@@]32C)=O

Molecular Formula

C24H30O6

Molecular Weight

414.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73 (13) : p. 1451-62.|[2]Myron H Weinberger, et al. Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am J Hypertens. 2002 Aug;15 (8) :709-16. |[3]Shlomo Keidar, et al. Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 2003 Jun;41 (6) :955-63.