N-Acetyl-L-aspartic acid

N-Acetyl-L-aspartic acid is a derivative of Aspartic acid (HY-N0666) and endogenous compound. N-Acetyl-L-aspartic acid acts as an acetyl donor. N-Acetyl-L-aspartic acid is involved in brain metabolism. N-Acetyl-L-aspartic acid is used in the research of neurodegenerative diseases (such as Canavan disease) [1][2][3][4][5][6].

Product Specifications

CAS Number

[997-55-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/N-Acetyl-L-aspartic_acid.html

Purity

99.45

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 62.5 mg/mL (ultrasonic)

Smiles

O=C(O)C[C@@H](C(O)=O)NC(C)=O

Molecular Formula

C6H9NO5

Molecular Weight

175.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Birken DL, et al. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev. 1989 Spring;13 (1) :23-31.|[2]Buniatian HC, et al. The participation of N-acetyl-L-aspartic acid in brain metabolism. J Neurochem. 1965 Aug;12 (8) :695-703. |[3]Sreekumar A, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457 (7231) :910-4. |[4]Karaman S, et al. Subchronic oral toxicity assessment of N-acetyl-L-aspartic acid in rats. Food Chem Toxicol. 2011 Jan;49 (1) :155-65.|[5]Karaman S, et al. Two-generation reproductive and developmental toxicity assessment of dietary N-acetyl-L-aspartic acid in rats. Food Chem Toxicol. 2011 Dec;49 (12) :3192-205.|[6]Delaney B, et al. Acute and repeated dose oral toxicity of N-acetyl-l-aspartic acid in Sprague-Dawley rats. Food Chem Toxicol. 2008 Jun;46 (6) :2023-34.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Available Sizes

Curated Selection

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