BTSA1
BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
Product Specifications
CAS Number
314761-14-3
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btsa1.html
Purity
99.77
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C4=CC=CC=C4)C3=N\NC5=NC=CS5
Molecular Formula
C21H14N6OS2
Molecular Weight
430.51
Precautions
H302
References & Citations
[1]Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32 (4) :490-505.e10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A04507-1-Fluoro550 100 µg/Vial
Anti-SCAP Antibody Picoband® Fluoro550 Conjugated
Sign In for Pricing
View Details 
039131-HRP 200 µL
NR4A3, CT (NR4A3, CHN, CSMF, MINOR, NOR1, TEC, Nuclear receptor subfamily 4 group A member 3, Mitogen-induced nuclear orphan receptor, Neuron-derived orphan receptor 1, Nuclear hormone receptor NOR-1) (Azide free) (HRP) discontinued
Sign In for Pricing
View Details