BTSA1

BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].

Product Specifications

CAS Number

[314761-14-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btsa1.html

Purity

99.77

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C4=CC=CC=C4)C3=N\NC5=NC=CS5

Molecular Formula

C21H14N6OS2

Molecular Weight

430.51

Precautions

H302

References & Citations

[1]Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32 (4) :490-505.e10.