Exendin-4 (acetate)

CC(O)=O.O=C(NCC(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(NCC(N5[C@@H](CCC5)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N8[C@@H](CCC8)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC9=CNC=N9)N

[1]Doyle ME, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114 (2-3) :153-8.|[2]Wei R, et al. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab. 2016 Jun 1;310 (11) :E947-57.|[3]Fidan-YaylalI G, et al. Antidiabetic exendin-4 activates apoptotic pathway and inhibits growth of breast cancer cells. Tumour Biol. 2016 Feb;37 (2) :2647-53.|[4]Ding X, et al. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/obmice. Hepatology. 2006 Jan;43 (1) :173-81.|[5]Nachnani JS, et al. Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas. Diabetologia. 2010 Jan;53 (1) :153-9.|[6]Sélley E, et al. Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production. Cardiovasc Diabetol. 2014 Apr 2;13:69.

Biomaterials. 2021 Aug;275:120944.|Acta Biochim Biophys Sin (Shanghai) . 2017 Jul 1;49 (7) :573-580.|Am J Physiol Cell Physiol. 2024 May 13.|Am J Physiol Endocrinol Metab. 2020 Dec 1;319 (6) :E1019-E1030.|Am J Physiol Endocrinol Metab. 2025 May 1;328 (5) :E661-E674.|Annals of the Romanian Society for Cell Biology. 2021 Mar 15.|Asian J Pharm Sci. 2024 Apr;19 (2) :100904.|Bioact Mater. 2025 Nov 25:57:646-659.|Biochem Pharmacol. 2025 Oct 30;243 (Pt 1) :117483.|Biochem Pharmacol. 2025 Sep 4;242 (Pt 2) :117306.|Biochim Biophys Acta Mol Cell Res. 2022 May 27;1869 (9) :119300.|Biomacromolecules. 2024 Aug 12;25 (8) :4946-4955.|Biomedicines. 2020 Nov 9;8 (11) :485.|bioRxiv. 2020 Jul.|bioRxiv. 2024 August 10.|bioRxiv. 2024 Mar 20:2024.03.18.585583.|bioRxiv. 2024 May 3.|bioRxiv. 2024 May 8.|bioRxiv. 2025 May 14.|BMC Biol. 2021 Mar 3;19 (1) :40.|Br J Pharmacol. 2020 Aug;177 (15) :3389-3402. |Br J Pharmacol. 2024 Oct;181 (19) :3556-3575.|Br J Pharmacol. 2025 Jan;182 (1) :52-68.|Cell Metab. 2025 Dec 2;37 (12) :2362-2380.e8.|Chem Biol Interact. 2019 May 1:304:186-193.|Diabetol Int. 2025 Jun 5;16 (3) :568-579.|Drug Deliv. 2022 Dec;29 (1) :548-560.|Eur J Pharmacol. 2024 Dec 5:984:177029.|Eur J Pharmacol. 2024 Nov 6:985:177106.|Exp Cell Res. 2023 Feb 15;423 (2) :113469.|Front Behav Neurosci. 2022 Jan 5:15:769664.|Front Pharmacol. 2019 Oct 25;10:1230.|Front Pharmacol. 2021 Jul 19;12:694476.|Gerontology. 2023;69 (5) :603-614.|Gut. 2023 Feb;72 (2) :314-324.|Inflamm Res. 2024 May 15.|Insects. 2024 Jul 5;15 (7) :503.|Int Immunopharmacol. 2021 Jan;90:107192.|Int Immunopharmacol. 2023 Jul:120:110339.|Int Immunopharmacol. 2024 Aug 1:140:112844.|Int J Biol Sci. 2022 Jan 16;18 (4) :1328-1346.|Int J Nanomedicine. 2025 Mar 17:20:3363-3378.|J Adv Res. 2025 Mar 10:S2090-1232 (25) 00174-2.|J Biol Chem. 2018 Nov 23;293 (47) :18086-18098. |J Cell Physiol. 2021 May;236 (5) :3641-3659.|J Diabetes Res. 2019 Dec 9;2019:8905917.|J Funct Foods. 2023 Aug, 107, 105706.|J Invest Dermatol. 2022 May;142 (5) :1349-1359.e8.|J Mol Histol. 2025 Jun 28;56 (4) :210.|J Neuroinflammation. 2019 Nov 28;16 (1) :242.|Mater Technol (N Y N Y) . 2025 Jun 17.|medRxiv. 2024 Jul 23.|Mol Med. 2024 May 8;30 (1) :58.|Mol Metab. 2023 Dec:78:101811.|Nature. 2025 May;641 (8061) :192-201.|Neural Regen Res. 2023 Aug;18 (8) :1818-1826.|Neurogastroenterol Motil. 2019 Feb;31 (2) :e13482.|Res Sq. 2024 Aug 11.|Sci Rep. 2017 Jun 28;7 (1) :4351.|Sci Rep. 2024 Jun 14;14 (1) :13726.|Seoul National University. 2025 Jan.|SSRN. 2019 Jun 27.|Structure. 2022 Apr 7;30 (4) :510-521.e3.