Itaconic acid
Product Specifications
UNSPSC Description
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].
Target Antigen
Endogenous Metabolite; Ferroptosis
Type
Natural Products
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/propylenedicarboxylic-acid.html
Purity
99.98
Solubility
H2O : 27.78 mg/mL (ultrasonic)
Smiles
O=C(O)C(CC(O)=O)=C
Molecular Weight
130.10
References & Citations
[1]Weiss JM, et, al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J Clin Invest. 2018 Aug 31;128(9):3794-3805.|[2]Zhao M, et, al. Itaconic acid production in microorganisms. Biotechnol Lett. 2018 Mar;40(3):455-464.|[3]Qu C, et al. Itaconic acid induces ferroptosis by activating ferritinophagy. Biochem Biophys Res Commun. 2021 Oct 25;583:56-62. |[4]Zhu X, et al. Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS. Sci Rep. 2021 Sep 13;11(1):18173.|[5]Umbrasas D, et al. Effects of itaconic acid on neuronal viability and brain mitochondrial functions. J Bioenerg Biomembr. 2021 Oct;53(5):499-511.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-Y0520/Itaconic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-Y0520/Itaconic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
97-65-4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
