Itaconic acid

Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].

Product Specifications

CAS Number

[97-65-4]

Product Name Alternative

Methylenesuccinic acid

UNSPSC

12352211

Hazard Statement

H318, H402

Target

Endogenous Metabolite; Ferroptosis

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/propylenedicarboxylic-acid.html

Purity

99.98

Solubility

H2O : 27.78 mg/mL (ultrasonic)

Smiles

O=C(O)C(CC(O)=O)=C

Molecular Formula

C5H6O4

Molecular Weight

130.10

Precautions

H318, H402

References & Citations

[1]Weiss JM, et, al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J Clin Invest. 2018 Aug 31;128 (9) :3794-3805.|[2]Zhao M, et, al. Itaconic acid production in microorganisms. Biotechnol Lett. 2018 Mar;40 (3) :455-464.|[3]Qu C, et al. Itaconic acid induces ferroptosis by activating ferritinophagy. Biochem Biophys Res Commun. 2021 Oct 25;583:56-62. |[4]Zhu X, et al. Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS. Sci Rep. 2021 Sep 13;11 (1) :18173.|[5]Umbrasas D, et al. Effects of itaconic acid on neuronal viability and brain mitochondrial functions. J Bioenerg Biomembr. 2021 Oct;53 (5) :499-511.