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Maurocalcine (TFA)

Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/maurocalcine-tfa.html

Purity

95.19

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(O)C(F)(F)F.O=C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H]1CCCCN)=O)=O)=O)NC2=O)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]5CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@H]2CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)NC5=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN.[x]

Molecular Formula

C156H270N56O46S6.xC2HF3O2

Molecular Weight

3858.55 (free base)

References & Citations

[1]De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477 (20) :3985-3999.|[2]Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758 (3) :308-19.|[3]Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758 (3) :308-19.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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