Withanolide A

Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases[1][2][3][4].

Product Specifications

CAS Number

[32911-62-9]

UNSPSC

12352005

Target

Apoptosis; Notch

Type

Natural Products

Related Pathways

Apoptosis; Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/withanolide-a.html

Purity

99.98

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C1O[C@@]([H])([C@@](C)([C@H]2CC[C@]3([C@@]4([C@H]5[C@@H]([C@@](O)(CC=CC6=O)[C@]6([C@]4(CC[C@@]32C)[H])C)O5)[H])[H])O)CC(C)=C1C

Molecular Formula

C28H38O6

Molecular Weight

470.60

References & Citations

[1]Kuboyama T, et al. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005 Apr;144 (7) :961-71..|[2]Zhang X, et al. Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A. Gynecol Oncol. 2012 Mar;124 (3) :606-12.|[3]Pathak P, et al. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation. J Ethnopharmacol. 2021 Oct 5;278:114296.|[4]Baitharu I, et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One. 2014 Oct 13;9 (10) :e105311.