Valacyclovir (hydrochloride)

Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml) . Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) [1][2][3][4][5].

Product Specifications

CAS Number

[124832-27-5]

Product Name Alternative

Valaciclovir hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; HSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/valacyclovir-hydrochloride.html

Purity

99.85

Solubility

DMSO : 43.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](C(C)C)C(OCCOCN1C=NC2=C1N=C(N)NC2=O)=O.Cl

Molecular Formula

C13H21ClN6O4

Molecular Weight

360.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Valacyclovir. New indication: for genital herpes, simpler administration. Can Fam Physician. 1999 Jul;45:1698-700, 1703-5.|[2]Lycke J, et al. Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir. Antimicrob Agents Chemother. 2003 Aug;47 (8) :2438-41.|[3]Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murineimmunosuppression model. Antimicrob Agents Chemother. 1995 May;39 (5) :1114-9.|[4]Dhaliwal DK, Romanowski EG, Yates KA, Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laser keratectomy. Cornea. 1999 Nov;18 (6) :693-9.|[5]Guo A, Hu P, Balimane PV, Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.J Pharmacol Exp Ther. 1999 Apr;289 (1) :448-54.