Nikethamide

Nikethamide (N, N-Diethylnicotinamide), one of the respiratory central stimulants, has the potential for respiratory failure research[1][2][3][4].

Product Specifications

CAS Number

[59-26-7]

Product Name Alternative

N, N-Diethylnicotinamide

UNSPSC

12352005

Hazard Statement

H301, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Nikethamide.html

Purity

99.87

Solubility

DMSO : < 1 mg/mL|H2O : ≥ 50 mg/mL

Smiles

O=C(C1=CC=CN=C1)N(CC)CC

Molecular Formula

C10H14N2O

Molecular Weight

178.23

Precautions

H301, H319

References & Citations

[1]Chen L, et al. Simultaneous determination of nikethamide and lidocaine in human blood and cerebrospinal fluid by high performance liquid chromatography. J Pharm Biomed Anal. 2007 Apr 11;43 (5) :1757-62.|[2]Koldaev VM. Effect of ephedrine and nikethamide on the outcome of microwave lesions in mice. Bull Exp Biol Med. 1974 Sep;77 (3) :298-301. |[3]Dulfano M J, et al. Nikethamide as a respiratory analeptic[J]. JAMA, 1963, 185 (2) : 69-74.|[4]MCNICOL MW, et al. Nikethamide for severe CO2 retention in exacerbations of chronic bronchitis. Br Med J. 1963 Mar 9;1 (5331) :646-8.