HIF-1 inhibitor-4
HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM) . HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].
Product Specifications
CAS Number
[333357-56-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1-inhibitor-4.html
Purity
99.50
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(CN2CCOCC2)C=C1)NC3=CC=C(C=C3)I
Molecular Formula
C18H19IN2O2
Molecular Weight
422.26
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22 (19) :5513-29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
47006154 3x 1.0 µg DNA
TMEM218 CRISPR All-in-one AAV vector set (with saCas9)(Mouse)
Sign In for Pricing
View Details 
MBS7014932-01 0.02 mg
Recombinant Drosophila ananassae Calcium channel flower (flower)
Sign In for Pricing
View Details MBS7014932-02 0.1 mg
Recombinant Drosophila ananassae Calcium channel flower (flower)
Sign In for Pricing
View Details MBS7014932-03 5x 0.1 mg
Recombinant Drosophila ananassae Calcium channel flower (flower)
Sign In for Pricing
View Details