HIF-1 inhibitor-4
Product Specifications
UNSPSC Description
HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].
Target Antigen
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1-inhibitor-4.html
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=CC=C(CN2CCOCC2)C=C1)NC3=CC=C(C=C3)I
Molecular Weight
422.26
References & Citations
[1]Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153017/HIF-1-inhibitor-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153017/HIF-1-inhibitor-4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
333357-56-5
Available Sizes
Curated Selection
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