HIF-1 inhibitor-4

HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM) . HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].

Product Specifications

CAS Number

[333357-56-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hif-1-inhibitor-4.html

Purity

99.50

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(CN2CCOCC2)C=C1)NC3=CC=C(C=C3)I

Molecular Formula

C18H19IN2O2

Molecular Weight

422.26

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22 (19) :5513-29.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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