HIF-1 inhibitor-4
HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM) . HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].
Product Specifications
CAS Number
[333357-56-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1-inhibitor-4.html
Purity
99.50
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(CN2CCOCC2)C=C1)NC3=CC=C(C=C3)I
Molecular Formula
C18H19IN2O2
Molecular Weight
422.26
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22 (19) :5513-29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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