Dehydroleucodine
Product Specifications
UNSPSC Description
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects[1][2][3].
Target Antigen
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dehydroleucodine.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3C(C=C(C)[C@@]31[H])=O)C2=C
Molecular Weight
244.29
References & Citations
[1]Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6.|[2]Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803.|[3]Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122295/Dehydroleucodine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122295/
Clinical Information
No Development Reported
CAS Number
36150-07-9
Available Sizes
Curated Selection
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