JNJ-37822681
JNJ-37822681 is a fast dissociating D2 antagonist with activity in inhibiting schizophrenia. JNJ-37822681 has high specificity for D2 receptors and is effective in animal models, inducing increased levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibiting antidepressant activity in the mouse tail suspension test, while having a good brain distribution and lower prolactin release.
Product Specifications
CAS Number
[935776-74-2]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jnj-37822681.html
Smiles
FC1=CC=C(CN2CCC(CC2)NC3=NN=C(C(F)(F)F)C=C3)C=C1F
Molecular Formula
C17H17F5N4
Molecular Weight
372.34
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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