MA-PEG4-VC-PAB-DMEA-duocarmycin DM

MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate for ADC by using the DNA minor-groove alkylator Duocarmycin DM (HY-130978), linked via MA-PEG4-vc-PAB-DMEA (HY-126668) .

Product Specifications

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ma-peg4-vc-pab-dmea-duocarmycin-dm.html

Purity

99.84

Solubility

10 mM in DMSO

Smiles

O=C(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(N(CCN(C(OC2=CC3=C([C@@H](CN3C(C4=CC5=CC(OCCN(C)C)=CC=C5N4)=O)CCl)C6=CC=CC=C26)=O)C)C)=O)C=C1)=O)CCCNC(N)=O)=O)C(C)C)=O)CCN7C(C=CC7=O)=O

Molecular Formula

C68H89ClN12O17

Molecular Weight

1381.96

References & Citations

[1]Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15 (5) :616-30.|[2]Italo Beria, et al. New alkylating agents. Franch, WO2013149948A1.