Tazofelone
Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].
Product Specifications
CAS Number
[107902-67-0]
Product Name Alternative
LY 213829
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tazofelone.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NCSC1CC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Molecular Formula
C18H27NO2S
Molecular Weight
321.48
Precautions
H302, H315, H319
References & Citations
[1]Leopold Franz Goetze, et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2.|[2]Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25 (12) :1383-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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