Tazofelone

Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].

Product Specifications

CAS Number

[107902-67-0]

Product Name Alternative

LY 213829

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tazofelone.html

Purity

99.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NCSC1CC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

Molecular Formula

C18H27NO2S

Molecular Weight

321.48

Precautions

H302, H315, H319

References & Citations

[1]Leopold Franz Goetze, et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2.|[2]Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25 (12) :1383-8.