Linopirdine dihydrochloride
KCNQ Channel Blocker
Product Specifications
Background
Linopirdine increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels (1-3). Linopirdine is a state-dependent blocker favoring activated single subunits of the channel (4).
CAS Number
113168-57-3
Product Name Alternative
1-Phenyl-3,3-bis (pyridine-4-ylmethyl) indolin-2-one, dihydrochloride; DuP996
UNSPSC
41116105
Type
Blocker
Source
Synthetic
Field of Research
Neuroscience | Neurotransmission | Ion Channels | Potassium Channels | Voltage-Gated Potassium Channels
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (25 mg/ml): or water (25 mg/ml)
Molecular Formula
C26H23Cl2N3O
Molecular Weight
464.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. D Kristufeck et al. J. Neurochem. 1999 72:2083
2. HS Wang et al. Science 1998 282:1890
3. DJ Fontana et al. Pharmacol. Biochem. Behav. 1994 49:1075
4. DL Greene et al. J. Pharmacol. Exp. Ther. 2017 362:177
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