AFD-21 (maleate)
AFD-21 maleate is a drug with antiarrhythmic activity. AFD-21 maleate inhibits sodium channels by binding to sodium channels in an inactive state, with both use-dependent and voltage-dependent effects. The unbinding rate of AFD-21 maleate is similar to that of Class I antiarrhythmic drugs with moderate kinetics. AFD-21 maleate can cause a slight prolongation of the action potential duration and significantly reduce the maximum rise rate of the action potential at certain concentrations. AFD-21 maleate also showed use-dependent blocking effects as stimulation frequency increased[1].
Product Specifications
CAS Number
99465-44-8
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/afd-21-maleate.html
Smiles
OC(C1=CC=CC=C1)(CCCN(CC(C)C)CC(C)C)C2=CC=CC=C2.O=C(O)/C=C\C(O)=O
Molecular Formula
C28H39NO5
Molecular Weight
469.61
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD45RO (190-2F2.5), CF405S conjugate, 0.1mg/mL
CD63 (MX-49.129.5), CF405S conjugate, 0.1mg/mL
Major Vault Protein (MVP) (1032), CF740 conjugate, 0.1mg/mL
