Cinnamtannin A2

Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect[1][2].

O[C@@H]([C@@H](C(C=C1)=CC(O)=C1O)O2)[C@@H](C(C(O)=C3)=C(O[C@H](C(C=C4)=CC(O)=C4O)[C@@H]5O)C([C@@H]5C(C(O)=C6)=C(O[C@H](C(C=C7)=CC(O)=C7O)[C@@H]8O)C(C8)=C6O)=C3O)C(C2=C([C@H]([C@H]([C@@H](C(C=C9)=CC(O)=C9O)O%10)O)C(C%10=CC(O)=C%11)=C%11O)C(O)=C%12)=C%12O

[1]Yamashita Y, et, al. Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 and insulin secretion in mice. Biosci Biotechnol Biochem. 2013;77(4):888-91.|[2]Li N, et, al. Cinnamtannin A2 protects the renal injury by attenuates the altered expression of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression in 5/6 nephrectomized rat model. AMB Express. 2020 May 8;10(1):87.|[3]Osakabe N, et, al. Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp Biol Med (Maywood). 2002 Jan;227(1):51-6.