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Human Kallikrein 3 Protein, His Tag (Pro-form, MALS verified)

Kallikrein-related peptidase 3, more commonly known as Kallikrein 3 (KLK3) or Prostate-Specific Antigen (PSA), is a serine protease belonging to the kallikrein family. Its primary function is to cleave proteins, and it is a key biomarker for prostate cancer. Secreted by the epithelial cells of the prostate gland, elevated levels of KLK3 in the blood are often indicative of prostate pathologies, including benign prostatic hyperplasia and prostate cancer. Beyond its role as a diagnostic marker, recent research explores its potential as a therapeutic target in cancer treatment. Its unique expression pattern and enzymatic function make it a subject of extensive research in oncology.

Product Specifications

Background

Kallikrein-related peptidase 3, more commonly known as Kallikrein 3 (KLK3) or Prostate-Specific Antigen (PSA), is a serine protease belonging to the kallikrein family. Its primary function is to cleave proteins, and it is a key biomarker for prostate cancer. Secreted by the epithelial cells of the prostate gland, elevated levels of KLK3 in the blood are often indicative of prostate pathologies, including benign prostatic hyperplasia and prostate cancer. Beyond its role as a diagnostic marker, recent research explores its potential as a therapeutic target in cancer treatment. Its unique expression pattern and enzymatic function make it a subject of extensive research in oncology.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.7 kDa. The protein migrates as 33-36 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P07288-1

Expression Region

Ala 18 - Pro 261

Host

HEK293

Target

Kallikrein 3

Conjugation

Unconjugated

Tag

C-10xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Format

Powder

Buffer

50 mM Tris, 150 mM NaCl, pH7.5

Additives

Trehalose

Molecular Weight

28.7 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

100ug*1

Host or Source

HEK293

Species

Human

Protein ID

P07288-1

Preservative

Trehalose

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