Sakuranetin

Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity[1]. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury[2].

Product Specifications

CAS Number

[2957-21-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Sakuranetin.html

Purity

99.94

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1C2=C(O)C=C(OC)C=C2O[C@H](C3=CC=C(O)C=C3)C1

Molecular Formula

C16H14O5

Molecular Weight

286.28

Precautions

H302

References & Citations

[1]Hasegawa M, et al. Analysis on blast fungus-responsive characters of a flavonoid phytoalexin sakuranetin; accumulation in infected rice leaves, antifungal activity and detoxification by fungus. Molecules. 2014 Aug 4;19 (8) :11404-18.|[2]Bittencourt-Mernak MI, et al. Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312 (2) :L217-L230.|[3]Kwon DH, et al. Suppression of influenza B virus replication by sakuranetin and mode of its action. Phytother Res. 2018 Dec;32 (12) :2475-2479. |[4]Drira R, et al. Sakuranetin Induces Melanogenesis in B16BL6 Melanoma Cells through Inhibition of ERK and PI3K/AKT Signaling Pathways. Phytother Res. 2016 Jun;30 (6) :997-1002.|[5]Toledo AC, et al. Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model. Br J Pharmacol. 2013 Apr;168 (7) :1736-49.