Benzamidine (hydrochloride hydrate)

Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1][2].

Product Specifications

CAS Number

[206752-36-5]

Product Name Alternative

Benzenecarboximidamide (hydrochloride hydrate)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Ser/Thr Protease

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/benzamidine-hydrochloride-hydrate.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(C1=CC=CC=C1)N.[H]Cl.[H]O[H].[x]

Molecular Formula

C7H8N2.ClH.xH2O

Precautions

H302, H315, H319, H335

References & Citations

[1]Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7 (4) :299-312.|[2]J A Cairns, et al. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J Clin Invest. 1997 Mar 15;99 (6) :1313-21.