HSP70-IN-1
HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
Product Specifications
CAS Number
1268273-90-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HSP70-IN-1.html
Concentration
10mM
Purity
98.07
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(SC2=CN=C(N3CCN(C)CC3)N=C2OCC4=CC=CC=C4)=C1)CN
Molecular Formula
C24H28N6O2S
Molecular Weight
464.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Taldone T, et al. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5- (phenylthio) pyrimidines, 2- (pyridin-3-ylthio) pyrimidines, and 3- (phenylthio) pyridines as reversible binders to an allosteric site on heat shock protein 70. J Med Chem. 2014 Feb 27;57 (4) :1208-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70
Available Sizes
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