HSP70-IN-1

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.

Product Specifications

CAS Number

[1268273-90-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HSP70-IN-1.html

Concentration

10mM

Purity

98.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(SC2=CN=C(N3CCN(C)CC3)N=C2OCC4=CC=CC=C4)=C1)CN

Molecular Formula

C24H28N6O2S

Molecular Weight

464.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Taldone T, et al. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5- (phenylthio) pyrimidines, 2- (pyridin-3-ylthio) pyrimidines, and 3- (phenylthio) pyridines as reversible binders to an allosteric site on heat shock protein 70. J Med Chem. 2014 Feb 27;57 (4) :1208-24.