(S) -MCPG
(S) -MCPG ((+) -MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS) -MCPG. (S) -MCPG can be used for the study of the function of mGluRs in spatial learning[2].
Product Specifications
CAS Number
150145-89-4
Product Name Alternative
(+) -MCPG
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_S_-MCPG.html
Purity
99.61
Solubility
1M NaOH : 22 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic; adjust pH to 13 with 1M NaOH)
Smiles
OC(C1=CC=C([C@](C)(N)C(O)=O)C=C1)=O
Molecular Formula
C10H11NO4
Molecular Weight
209.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39 (7) :1130-7.|[2]F Bordi, et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35 (11) :1557-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR
Available Sizes
Frequently Asked Questions
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