(S) -MCPG

(S) -MCPG ((+) -MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS) -MCPG (HY-100371) [1]. (S) -MCPG can be used for the study of the function of mGluRs in spatial learning[2].

Product Specifications

CAS Number

[150145-89-4]

Product Name Alternative

(+) -MCPG

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_S_-MCPG.html

Purity

99.61

Solubility

1M NaOH : 22 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic; adjust pH to 13 with 1M NaOH)

Smiles

OC(C1=CC=C([C@](C)(N)C(O)=O)C=C1)=O

Molecular Formula

C10H11NO4

Molecular Weight

209.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39 (7) :1130-7.|[2]F Bordi, et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35 (11) :1557-65.