BC-1293
BC-1293 is an inhibitor for E3 ligase subunit FBXO24. BC-1293 disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) and increases the level of DARS2. BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, and exhibits immunostimulatory activity in mice[1].
Product Specifications
CAS Number
1219395-86-4
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bc-1293.html
Smiles
O=S(C1=CC(C2=NOC(C3CC3)=N2)=CC=C1C)(NC(C(N4CCC(C5=CC=CC=C5)=CC4)=O)C)=O
Molecular Formula
C26H28N4O4S
Molecular Weight
492.59
References & Citations
[1]Johnson BS, et al., Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses. Nat Commun. 2024 Jul 22;15 (1) :6172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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