18-Crown-6-ether

18-Crown-6-ether is a type of crown ether compound and a specific structure dissociating agent. 18-Crown-6-ether can compete with K+ for binding to G-quadruplexes, disrupting their stable structure to regulate the functions of related systems. 18-Crown-6-ether combines with K+ and other metal ions to achieve precise ion transmembrane transport. 18-Crown-6-ether can act as an "susceptibility substrate" for the multi-drug efflux pump EmrE (a bacterial multidrug resistance transporter), ultimately inhibiting bacterial growth. 18-Crown-6-ether can be used in microcapsule controlled release and the research on developing antibacterial enhancers[1][2][3].

Product Specifications

CAS Number

[17455-13-9]

Product Name Alternative

18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane

UNSPSC

12352200

Hazard Statement

H302

Target

Bacterial

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/18-crown-6-ether.html

Purity

99.77

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O1CCOCCOCCOCCOCCOCC1

Molecular Formula

C12H24O6

Molecular Weight

264.32

Precautions

H302

References & Citations

[1]Lilienthal S, et al. Single and Bilayer Polyacrylamide Hydrogel-Based Microcapsules for the Triggered Release of Loads, Logic Gate Operations, and Intercommunication between Microcapsules. ACS Appl Mater Interfaces. 2020 Jul 15;12 (28) :31124-31136.|[2]Fong C W. Physiology of ionophore transport of potassium and sodium ions across cell membranes: Valinomycin and 18-Crown-6 Ether. International Journal of Computational Biology and Drug Design, 2016, 9 (3) : 228-246.|[3]Brousseau M, et al. 18-Crown-6-ether Utilizes Distinct Allosteric Interactions to Uncouple Transport by the Multidrug Efflux Pump EmrE. Biochemistry. 2025 Sep 16;64 (18) :3956-3970.