Spantide II

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3].

Product Specifications

CAS Number

[129176-97-2]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/spantide-ii.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCCC)=O)=O)CC2=CNC3=CC=CC=C23)=O)[C@H](NC([C@H](CC(N)=O)NC([C@H](NC([C@H](CCC4)N4C([C@H](CC5=CN=CC=C5)NC([C@H](CCC6)N6C([C@H](N)CCCCNC(C7=CN=CC=C7)=O)=O)=O)=O)=O)CC(C=C8)=CC(Cl)=C8Cl)=O)=O)CC9=CNC%10=CC=CC=C9%10

Molecular Formula

C86H104Cl2N18O13

Molecular Weight

1668.76

References & Citations

[1]Xu XJ, et al. Spantide II, a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw. Neuroscience. 1991;42 (3) :731-7. |[2]Kikwai L, et al. In vitro and in vivo evaluation of topical formulations of spantide II. AAPS PharmSciTech. 2005 Oct 31;6 (4) :E565-72. |[3]Babu RJ, et al. Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II. Pharm Res. 2004 Jan;21 (1) :108-13.