Recombinant Human CCL3

Recombinant human CCL3

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

rHuCCL3-biotin, MIP-1alpha

Gene Name

CCL3

UniProt

P10147

Cellular Locus

Secreted.

Reactivity

Human

Target Antigen

C-C motif chemokine 3

Target

CCL3ylated

Type

Protein

Applications

Migration assay

Dilution

Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

Form

Lyophilized

Function

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. RPubMed:8525373}.

Additionnal Information

Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay of recombinant CCR5- expressing cells.

Storage Conditions

12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.

Specificity

CCL3ylated

Target Background

CCL3, also known as Macrophage Inflammatory Protein-1a (MIP-1a), is a proinflammatory chemokine that stimulates chemotaxis and activation of different cell populations of the immune system. CCL3 binds to CCR1, CCR4, and CCR5 receptors, and it is one of the major HIV- suppressive factors produced by CD8+ T-cells. CCL3 induces dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).