TAI-1
TAI-1, an orally active anticancer agent, is a highly potent first-in-class Hec1 inhibitor, with a GI50 of 13.48 nM in K562 cells[1].
Product Specifications
CAS Number
[1334921-03-7]
UNSPSC
12352005
Target
Apoptosis; NEKs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tai-1.html
Concentration
10mM
Purity
98.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(OC4=CC=C(OC)C=C4)C=C3C)=CS2
Molecular Formula
C24H21N3O3S
Molecular Weight
431.51
References & Citations
[1]Lynn Y L Huang, et al. Characterization of the Biological Activity of a Potent Small Molecule Hec1 Inhibitor TAI-1. J Exp Clin Cancer Res. 2014 Jan 9;33 (1) :6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NEK2
Available Sizes
Curated Selection
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