TAI-1

TAI-1, an orally active anticancer agent, is a highly potent first-in-class Hec1 inhibitor, with a GI50 of 13.48 nM in K562 cells[1].

Product Specifications

CAS Number

[1334921-03-7]

UNSPSC

12352005

Target

Apoptosis; NEKs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tai-1.html

Concentration

10mM

Purity

98.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(OC4=CC=C(OC)C=C4)C=C3C)=CS2

Molecular Formula

C24H21N3O3S

Molecular Weight

431.51

References & Citations

[1]Lynn Y L Huang, et al. Characterization of the Biological Activity of a Potent Small Molecule Hec1 Inhibitor TAI-1. J Exp Clin Cancer Res. 2014 Jan 9;33 (1) :6.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NEK2

Available Sizes

Curated Selection

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