GSK3145095

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].

Product Specifications

CAS Number

[1622849-43-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk3145095.html

Purity

99.39

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=CC2=C1NC([C@@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O

Molecular Formula

C20H17F2N5O2

Molecular Weight

397.38

Precautions

H302, H315, H319

References & Citations

[1]Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10 (6) :857-862.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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