GSK3145095
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
Product Specifications
CAS Number
[1622849-43-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk3145095.html
Purity
99.39
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC1=CC(F)=CC2=C1NC([C@@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O
Molecular Formula
C20H17F2N5O2
Molecular Weight
397.38
Precautions
H302, H315, H319
References & Citations
[1]Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10 (6) :857-862.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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