Quinacrine mustard (dihydrochloride)

Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes[1][2][3].

Product Specifications

CAS Number

[4213-45-0]

UNSPSC

12171500

Hazard Statement

H301+H331, H317, H334, H361

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/quinacrine-mustard-dihydrochloride.html

Purity

95.01

Solubility

H2O : 6.25 mg/mL (ultrasonic; warming)

Smiles

CC(CCCN(CCCl)CCCl)N=C1C2=C(C=C(C=C2)Cl)NC3=C1C=C(C=C3)OC.Cl.Cl

Molecular Formula

C23H30Cl5N3O

Molecular Weight

541.77

Precautions

H301+H331, H317, H334, H361

References & Citations

[1]Caspersson T, et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science. 1970 Nov 13;170 (3959) :762.|[2]Piosik J, et al. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res. 2003 Sep 29;530 (1-2) :47-57.|[3]Kapuscinski J, et al. The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine. Biochem Pharmacol. 2002 Feb 15;63 (4) :625-34.